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Josh Mitteldorf's avatar

Very wise and balanced advice, thank you!

Here's a story from my researches. My daughter has high cholesterol, and she asked me ten years ago whether she should worry about it. (She was 28.) I spent two weeks reading the literature, and wrote up the results in my blog. https://joshmitteldorf.scienceblog.com/2014/05/14/cholesterol-a-medical-controversy-i-background/

What I found was that there were two schools of thought, both published in top-tier journals by professors from the best med schools. One school was that lowering LDL was crucial to lowering risk of cardiovascular events. The other said that LDL had little to do with heart attacks and, if anything, there was a negative correlation between cholesterol in the blood and CV risk.

At the time, I reported to my daughter that there was a basic disagreement among experts, and that I didn't have the background to be able to distinguish where the truth lay. If I were answering the same question today, I would say that this is an asymmetrical debate, since one side is supported by statin drug prescriptions, one of the most profitable lines of pharmaceutical products. I would note that one side has financial motivation to skew their professional judgment, while the other side is probably in an uphill battle just to get their studies into print.

Listen to the experience of Aseem Malhotra: https://www.youtube.com/watch?v=CV-Qbbl_e6o

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JayBee's avatar

I just finished watching your interview. Ever since I found you via your vaccine conference attendance piece, you are the writer I look forward to most for new articles on substack.

I also had quite a few doctor friends, one a top heart surgeon, and it was indeed astonishing how trusting and self-assured they were and how little they know about the very basics around anything related to Covid, like IFR, ct cycles or absolute vs relative risk, let alone HI threshold/VE formulas, which I fortunately got made aware of by Bartram's article 'The never ending quest for herd immunity', whereafter all the then still missing pieces about their (basically slavishly following the Roy Anderson booster etc.) strategy (linked to in Bartram's piece) fell into place for me.

Even more shocking and telling was and is, that they showed zero curiosity and interest in aquiring that basic knowledge- as with the other topics you mentioned from JFK via moon landings to climate change or the origins of the Ukraine conflict.

Personally, I think I am different than them thanks to my career in equity markets, where you are wrong every day and most times, and toast quickly if you can't take responsibility for these mistakes and refuse to learn from them.

Being introduced to Gustave Lebon's The Crowd was the 2nd important step for my journey and development.

Thank you! Off to ordering your book now!

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